Invokana side effects may include ketoacidosis, coma, foot and leg amputations and other serious kidney and cardiovascular complications. Affected patients may be entitled to compensation. A recent U.S. Food and Drug Administration (FDA) Safety Communication found that canagliflozin and other SGLT2 inhibitors are associated with life-threatening adverse reactions.
If you or a loved one took one of these Type 2 diabetes medications and suffered complications, including ketoacidosis, contact Attorney Group today to discuss your legal options for free.
Invokana Ketoacidosis Risks
Manufactured by Johnson & Johnson, Invokana is an SGLT2 inhibitor, which is a class of medications intended to help those with Type 2 diabetes lower their blood sugar. SGLT2 inhibitors work by causing the kidneys to remove sugar through the urine, lowering the body’s overall glycemia level.
According to the FDA Safety Communication, this medication may, however, increase the risk of ketoacidosis, a condition that occurs when dangerous levels of acids called ketones accumulate in the blood. This can occur if insulin levels in the body are too low, and may require hospitalization. In some cases, ketoacidosis can lead to a diabetic coma and even death.
Signs and Symptoms of Ketoacidosis
Patients who are suffering from ketoacidosis may exhibit the following symptoms:
- Nausea and vomiting
- Difficulty breathing
- Abdominal pain
- Unusual fatigue
Ketoacidosis May Lead to Diabetic Coma
Although diabetic ketoacidosis typically develops slowly, it can be serious if left untreated. The dangerous combination of low blood sugar, dehydration, shock, and extreme fatigue could result in a diabetic coma.
While Invokana has, to date, not been the subject of any known recalls, the U.S. Food and Drug Administration is asking patients who are prescribed the drug to exercise caution, in part because of its link to the development of this side effect.
Invokana Amputation Risk
In May 2016, a second FDA safety announcement cautioned the public about a new risk of losing a limb associated with the diabetes drug. After a brief investigation, interim results suggested that amputations occurred about twice as often in patients treated with Invokana compared to those treated with a placebo. The preliminary data from the clinical trial found that seven in 1,000 subjects taking canagliflozin ended losing a foot or leg compared to three in 1,000 subjects taking a placebo.
Patients treated with this antidiabetes agent should notify their healthcare professionals immediately if they notice any new pain or tenderness, sores or ulcers, or infections in their legs or feet. However, the agency added that patients should not stop or change their diabetes medicines without first consulting their prescriber, as doing so may lead to uncontrolled blood sugar levels, blindness, nerve and kidney damage, and heart disease.
The agency states that it is continuing to evaluate this safety issue and will update the public when more information becomes available. The FDA urged doctors and patients to report any serious side effects to the MedWatch program.
Other Invokana Side Effects
Potential Invokana side effects include:
- Kidney Failure
- Heart Attack
- Urinary tract infections
- Bone fractures
Canagliflozin and other SGLT2 inhibitors received label updates in 2015 after the FDA discovered that this class of drugs was linked to several serious adverse reactions.